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W. Wang, Q. L. Guo, Q. D. You, K. Zhang, Y. Yang, J. Yu, W. Liu, L. Zhao, H. Y. Gu, Y. Hu, Z. Tan and X. T. Wang, “The Anticancer Activities of Wogonin in Murine Sarcoma S180 Both in vitro and ex vivo,” Biological & Pharmaceutical Bulletin, Vol. 29, No. 6, 2006, pp. 1132-1137. doi:10.1248/bpb.29.1132

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• TITLE: Long-Term Treatment with a Compound Polysaccharide-Based Health Product (Infinitus Polysac Plus) Enhances Innate and Adaptive Immunity in Mice

  AUTHORS: Hoi-Yan Leung, Chung-Wah Ma, Qing Tao Tang, Kam-Ming Ko

  KEYWORDS: Compound Polysaccharide, Innate Immunity, Adaptive Immunity

  JOURNAL NAME: Chinese Medicine, Vol.2 No.4, December 9, 2011

  ABSTRACT: This study aimed to investigate the effects of a compound polysaccharide-based health product (Infinitus Polysac Plus, IPP) on innate and adaptive immunity in mice. Both ex vivo/in vivo mouse models and an in vitro system using cultured mouse splenocytes were adopted for the assessment of innate and adaptive immunity. For the innate immune response, long-term IPP treatment (0.26 and 0.78 g/kg * 20 doses) enhanced the carbon clearance activity and phagocytic rate of macrophages, as well as natural killer cell activity in mice. The IPP-induced increase in natural killer cell activity was accompanied by the suppression of tumor growth in Sarcoma-180 cell-inoculated mice. For the adaptive immune response, while long-term IPP treatment increased the splenocyte index in mice, IPP incubation with mouse splenocytes in vitro potentiated their concanavalin A-stimulated proliferation. Long-term IPP treatment significantly restored the hemolytic activity of serum on sheep red blood cells and dinitrofluorobenezene-induced delayed-type hypersensitivity in sensitized and immunosuppressed mice. In conclusion, the results indicate that long-term IPP treatment produces stimulatory effects on both innate and adaptive immunity in mice.