TITLE:
Acute Kidney Injury Caused by Darunavir in a Patient with COVID-19: A Case Report
AUTHORS:
Shiema Abdalla, Lenah Elgassim, Fatima Rustom, Muftah Othman
KEYWORDS:
COVID-19, Darunavir, Acute Kidney Injury, SARS-CoV-2
JOURNAL NAME:
Open Journal of Nephrology,
Vol.10 No.4,
December
18,
2020
ABSTRACT: Background: A highly contagious virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a pandemic globally. HIV medications were one of the suggested treatments for Coronavirus disease 2019 (COVID-19). Here, we report an unusual adverse drug reaction with darunavir in a SARS-CoV-2-infected patient. Case Presentation: This is a case presentation of a 53-year-old male with no past medical history who was diagnosed with COVID-19. One week after initiating treatment, the patient developed acute kidney injury, and his serum creatinine increased significantly. Conclusion: As there was no clear justification for renal impairment such as a prerenal or postrenal cause, acute kidney injury, possibly crystal-induced nephropathy, was considered an adverse drug reaction from darunavir.