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Peles, E., Nativ, M., Lustig, M., Grumet, M., Schilling, J., Martinez, R., et al. (1996) Identification of a Novel Contac-Tin-Associated Transmembrane Receptor with Multiple Domains Implicated in Protein-Protein Interactions. The EMBO Journal, 16, 978-988. https://doi.org/10.1093/emboj/16.5.978

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• TITLE: Regulation of Hematopoietic Activity Involving New Interacting Partners (RRAGC & PSMC2, CKAP4 & MANF and CTR9 & CNTNAP2)

  AUTHORS: Swati Sharma, Gurudutta U. Gangenahalli, Upma Singh

  KEYWORDS: Hematopoietic Stem Cells (HSCs), Signal Transduction, Haematopoiesis

  JOURNAL NAME: CellBio, Vol.9 No.3, September 30, 2020

  ABSTRACT: Hematopoietic stem cells (HSCs) are tissue-specific cells giving rise to all mature blood cell types regulated by a diverse group of hematopoietic cytokines and growth factors that influences the survival & proliferation of early progenitors and differentiation mechanisms by modulating the functional activities of HSCs. In this study, the functional yet distinctive role of three novel combinations of gene pairs RRAGC & PSMC2; CKAP4 & MANF; and CTR9 & CNTNAP2 have been newly identified. These novel combinations of genes were confirmed and expressed in K562 human leukemic cell line in the presence of cytokine combination (IL-3, FLT-3 and SCF) using RT-PCR and siRNA-mediated gene knock down strategy. This study signifies the synergistic role of gene pairs in different molecular activities like ubiquitination or proteasomal degradation, calcium mobilization, dopamine signaling.