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Zhao, J.H.., Zhai, B., Gygi, S.P. and Goldberg, A.L. (2015) mTOR Inhibition Activates Overall Protein Degradation by the Ubiquitin Proteasome System as Well as by Autophagy. Proceedings of the National Academy of Sciences of the United States of America, 112, 15790-15797. https://doi.org/10.1073/pnas.1521919112

has been cited by the following article:

• TITLE: Regulation of Hematopoietic Activity Involving New Interacting Partners (RRAGC & PSMC2, CKAP4 & MANF and CTR9 & CNTNAP2)

  AUTHORS: Swati Sharma, Gurudutta U. Gangenahalli, Upma Singh

  KEYWORDS: Hematopoietic Stem Cells (HSCs), Signal Transduction, Haematopoiesis

  JOURNAL NAME: CellBio, Vol.9 No.3, September 30, 2020

  ABSTRACT: Hematopoietic stem cells (HSCs) are tissue-specific cells giving rise to all mature blood cell types regulated by a diverse group of hematopoietic cytokines and growth factors that influences the survival & proliferation of early progenitors and differentiation mechanisms by modulating the functional activities of HSCs. In this study, the functional yet distinctive role of three novel combinations of gene pairs RRAGC & PSMC2; CKAP4 & MANF; and CTR9 & CNTNAP2 have been newly identified. These novel combinations of genes were confirmed and expressed in K562 human leukemic cell line in the presence of cytokine combination (IL-3, FLT-3 and SCF) using RT-PCR and siRNA-mediated gene knock down strategy. This study signifies the synergistic role of gene pairs in different molecular activities like ubiquitination or proteasomal degradation, calcium mobilization, dopamine signaling.