TITLE:
Clinicopathological Profile of Lung Cancers at an Institute from South India—A Record Based Retrospective Cohort Study
AUTHORS:
Vinod Ramani, Choudhury Bijit, Sarathy Vinu, Jayappa Srinivas Belagutti, Naik Radheshyam
KEYWORDS:
Lung Neoplasms, Adenocarcinoma, Squamous Cell Carcinoma, Small Cell Lung Carcinoma
JOURNAL NAME:
Advances in Lung Cancer,
Vol.9 No.3,
September
30,
2020
ABSTRACT: Introduction: Apart from smoking as the known risk factor for lung cancer, recent
developments implicate occupational exposure to carcinogens, indoor air
pollution and dietary factors as other causative agents. In our study, we have
analyzed the clinical and pathological profile of lung cancer patients treated
at our center over a period of 8 years. Aim: To find the demographic and clinicopathological profile of lung cancer
patients admitted to the oncology unit. Methods: This retrospective record based analysis includes a cohort of 1248
patients diagnosed with lung cancer, at a tertiary cancer care center in
Bangalore, South India. This study includes data of patients admitted during
the period 2010 to 2018, retrieved from the Hospital’s Electronic Medical Records (EMR). Their demographic profile, clinical correlates, radiological
profile and diagnostic details were studied. Benign tumours, malignant pleural
disease and sarcomatoid tumors were excluded from this study. Results: Adenocarcinoma (AC) was detected among 70.4% of patients, Squamous cell carcinoma (SCC) among 15.3% and Small cell lung
cancer (SCLC) among 14.3% of lung cancer admissions. Male to female ratio was
2.95:1. It was found that the median age of lung cancer patients was 61 years.
>60% of lung cancer patients were from the 51 - 70 year age-group. Across the three types of cancers among the patients
in Stage 3B to 4 strata, >35% received palliative chemotherapy and >20%
received palliative chemotherapy + radiation. Conclusion: In our study, AC is the most common histological
subtype (>70%) of lung cancer. The outcome of lung cancer patients can be
considerably impacted by addressing risk factors through preventive measures
implemented in the community.