TITLE:
Acute Lymphoblastic Leukemia in Childhood Following Pyoderma Gangrenosum
AUTHORS:
Aziza El Ouali, Manal Azizi, Nadia Bouhafs, Mounia Rimani, Ayad Ghannam, Abdeladim Babakhouya, Maria Rkain, Noufissa Benajiba
KEYWORDS:
Pyoderma Gangrenosum, Childhood, Leukemia
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.11,
November
23,
2020
ABSTRACT: Pyoderma
gangrenosum (PG) is a rare but serious ulcerating skin disease that occurs
either idiopathically or associated with various systemic diseases and
malignant tumors. Although the association of PG with myeloid malignant tumors
is well known, their association with lymphoid malignant tumors, especially in
children is extremely rare. We present here a case of PG in a 4-year and 4 months female child, diagnosed in the Pediatrics department, which had initially evolved well with oral
corticosteroid therapy and a local dermocorticoid. The development was marked 7
months after stopping corticosteroid treatment by the occurrence of acute
lymphoblastic leukemia. This case of PG is presented in the intention of increasing awareness of
this uncommon condition with may occurring in association with haematological malignancy. PG may precede, develop
concurrently with, or follow various conditions.