TITLE:
Triglyceride and Glucose Index (TyG) is a Reliable Biomarker to Predict Non-Alcoholic Fatty Liver Disease
AUTHORS:
Sania Hossain, Suraya Sultana, Khan Md. Shahariar Zaman, Sabrina Shafiq, A. K. M. Shahidur Rahman, Shah Md. Zakir Hossain, Saiful Islam, Mahammod Selim Uddin, Md. Omar Faroque, Sheuly Ferdoushi, Debatosh Paul, Md. Quddusur Rahman
KEYWORDS:
Non-Alcoholic Fatty Liver Disease (NAFLD), Plasma Glucose, Serum Triglyceride, Triglyceride and Glucose Index (TyG)
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.8 No.11,
November
18,
2020
ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease worldwide. There is no specific biomarker for the diagnosis of NAFLD. Trigly-ceride and glucose index (TyG) may predict the subsequent occurrence of NAFLD in later life. This cross sectional study was aimed to evaluate the effectiveness of triglyceride and glucose index (TyG) as a possible biomarker of NAFLD. The study was conducted at the Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from March 2019 to February 2020. A total of 124 subjects were taken as study population following selection criteria. Among them 62 were diagnosed patients of NAFLD and 62 were healthy subjects as control group. Fasting plasma glucose was measured by glucose oxidase method and serum triglyceride was measured by enzymatic-colorimetric method, while TyG index was calculated accordingly. The mean age was 39.5 ± 11.27 years in NAFLD patients and 37.10 ± 12.28 years in control subjects with male female ratio 1:1.7 and 1:1.8 respectively. Major portion of NAFLD patients (62.9%) were overweight (BMI ≥ 25). The mean fasting plasma glucose level was 5.73 ± 1.47 mmol/L in NAFLD patients and 5.27 ± 0.69 mmol/L in control group (p