TITLE:
Oxidative Cascade Prognosis, Antioxidants & Selected Trace Elements in COVID-19
AUTHORS:
Rizwan Ahmad Ansari, Karimah Mohammed Rabiu
KEYWORDS:
COVID-19, COPD, ROS, Oxidative Stress, Cytokines, Inflammation
JOURNAL NAME:
Open Journal of Applied Sciences,
Vol.10 No.11,
November
13,
2020
ABSTRACT: COVID-19
pandemic has now become a challenging global public health concern, having
higher risk of developing fatal respiratory disease due to severe inflammatory
responses associated with the virus-mediated oxidative stress. The respiratory
system is most preferred target organ for this novel virus as the lung is well
oxygenated and having large surface area available to the virus for exposure
and successively augmenting the health complications. Oxidative stress (OS) is
an important factor causing metabolic and physiological alteration and various
disease augmentations within the body. Respiratory viral infection has general
consociation with cytokine production, inflammation, cell death and other
pathophysiological processes which may be the result of perturbed redox
balance. Apart from this, the presence of conditions likes aging, diabetes and
hypertension and chronic obstructive pulmonary diseases (COPD) are the risk
factor for making severity of such infection outcome. It has been well
established that an overproduction of reactive oxygen species (ROS) and antioxidant
mechanisms deprivation are vital step for viral replica production and
consequent release of pro-inflammatory cytokines is also an important factor of the innate immune
responses to the pathogens that may result into acute lung damage. Additionally, ROS can damage various
vital biological molecules and inactivation of essential enzymes. Oxidative
stress is an important factor causing metabolic and other pathophysiological
alterations, such
as protein oxidations and various associated diseases. Therefore, in this paper, the significant adverse
impact of virus on host cell and underlying possible biochemical mechanism has
been discussed.