TITLE:
Wide Applications of Chloroquine Other Than Antimalarial
AUTHORS:
Baraa G. Alani, Ameer H. Alwash, Ismail T. Ibrahim
KEYWORDS:
Chloroquine, Antimalarial, Anticancer, Autophagy
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.11 No.10,
October
31,
2020
ABSTRACT: Chloroquine (CQ) was and still considered as the most
common agent in the treatment and prophylaxis of malaria, it also possesses many different
pharmacological and biological activities that make it able to be used as a
therapy or adjuvant therapy for many types of diseases. CQ exhibits anticancer
activity alone or as adjuvants with other agents against many kinds of tumors.
Its activities also were approved as an anti-inflammatory agent in rheumatoid and other autoimmune diseases like
systemic lupus and rheumatic arthritis. Its’ important role in the improvement of many metabolic disorders like
hypertension, hyperglycemia, and lipid profile disturbances was also
established. CQ can act against different microbial infections such as many
types of viruses, bacteria and fungus by different mechanisms of action. Furthermore, its
dermatological role in the treatment of many skin diseases was demonstrated. Recently, CQ showed a very
responsive role in curing and prevention of the covoid-19 virus. This review summarizes intensively the multiple
therapeutic applications of CQ and discusses the possible mechanisms of action
for these applications.