TITLE:
Conformational Radiotherapy of Prostatic Adenocarcinoma at the Dalal Jamm Hospital, Senegal—(Retrospective Analysis of a Series of 62 Cases)
AUTHORS:
Mouhamadou Bachir Ba, Amadou Ibra Diallo, Fatimatou Néné Sarr, El Hadji Aliou Baldé, Ibrahima Thiam, Papa Macoumba Gaye
KEYWORDS:
Cancer, Prostate, Radiotherapy, Senegal
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.10,
October
27,
2020
ABSTRACT: Aim: We endeavored to describe the epidemiological profile of prostatic
cancer, and to evaluate its diagnostic and therapeutic aspects. Method: We conducted a descriptive retrospective study on the conformational
radiotherapy of prostatic adenocarcinoma at the Dalal Jamm University Hospital,
Senegal from June 2018 to December 2019. We included 62 consecutive patients.
The average age of the patients was 68.9 years. The average consultation time
was 7.6 months. Results: Symptom manifestation and high PSA triggered
the diagnosis of cancer in 74.2% and 25.8% of patients, respectively. Symptoms:
pollakiuria (72.3%), bone pain (8%) and erectile dysfunction (4.8%). The
digital rectal examination: normal (33.8%), nodular (30.6%), induration
(24.1%), and shielding (11.3%). The mean PSA level was 90.6 ng/ml. Histology:
adenocarcinoma was the most common (98.6%). The Gleason score: 7 (19.4%). The majority of patients were in the high-risk
group (70.9%) and 7 patients (11.2%) were metastatic at diagnosis. Therapy:
first radical prostatectomy (20.9%), first-line curative radiotherapy (67.8%),
adjuvant (21%) and palliative radiotherapy in 7 patients (11.2%): patients
having received palliative radiotherapy had an estimated decline in symptoms of
80%. Hormone therapy was performed in 88.8% of patients, with average duration
of 12.5 months. After a mean follow-up of 15 months, 59 patients were alive,
including 45 cases (81.8%) in complete remission; 3 patients with metastasis at
the first visit (having received palliative radiotherapy)
died. Conclusion: The collected data show a profile of prostate cancer
that is specific to the sub-Saharan context in which the discovery is still
late. Also in comparison to developed countries, the therapeutic means necessary to fight against this cancer are limited, even though
three-dimensional conformational radiotherapy remains an effective and
essential treatment; this study provided fundamental data in the area of
insufficient data/tools.