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Namara, C.R., Mandel-Brehm, J., Bautista, D.M., Siemens, J., Deranian, K.L., Zhao, M., Hayward, N.J., Chong, J.A., Julius, D. and Moran, M.M. (2007) TRPA1 Mediates Formalin-Induced Pain. Proceedings of the National Academy of Sciences of the United States of America, 104, 13525-13530.
https://doi.org/10.1073/pnas.0705924104

has been cited by the following article:

• TITLE: Leaves Aqueous Extract of Boerhavia coccinea Induces Antinociceptive Effect but Increases Nitric Oxide Production in Macrophages

  AUTHORS: Basile N. Piegang, Douglas A. M. Ngangoum, Sorelle M. Ngassam, Pius P. Tseuguem, Bibiane A. Wandji, Desiré F. T. Bomba, Aliance R. Fokoua, Télesphore B. Nguelefack

  KEYWORDS: Boerhavia coccinea, Aqueous Extract, Analgesic, Macrophage, Nitric Oxide

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.8 No.10, October 21, 2020

  ABSTRACT: Pain treatment is one of the most challenging situations of the modern medicine. To overcome the actual limitations, new strategies should be developed and phytotherapy represents a promising alternative. Boerhavia coccinea is a medicinal plant used for the treatment of pain. The present work was undertaken to evaluate the antinociceptive effects of crude aqueous extract of the leaves of Boerhavia coccinea (AE) on acute pain and examine its mechanism of action. The analgesic effect of AE was evaluated at doses 50, 100, 200 and 400 mg/kg using the formalin-induced nociception in mice. The specific analgesic effect of AE was verified by testing its effect of AE on the sleep induced by diazepam. The anti-inflammatory effects of AE were also tested in vivo (100 and 200 mg/kg) on CFA-induced inflammation and in vitro (1 to 300 μg/ml) on the production of NO by non-activated or activated (LPS, 1 μg/l) macrophages. The effect of AE in non-stimulated macrophages was evaluated in absence and in presence of L-NAME (100 μg/ml) or dexathetasone (30 μg/ml). AE administered orally significantly (p st phase and 90% at the 2nd phase, but did not show any anti-inflammatory effect. AE at 50 mg/kg increased the latency to sleep and reduced sleep duration. AE drastically (p