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Yokoyama, M., Origosa, H., Matsuzaki, M., Matsuzawa, Y., Saito, Y., Ishikawa, Y., Oikawa, S., Sasaki, J., Hishida, H., Itakura, H., et al. (2007) Effects of eicosapentaenoic acid on major coronary events in hypercholesterolamic patients (JELIS): a randomized open-label, blinded endpoints analysis. The Lancet, 369, 1090-1098.
https://doi.org/10.1016/S0140-6736(07)60527-3

has been cited by the following article:

• TITLE: Fatty Acid Treatment with Pure Omega-3 Eicosapentaenoic Acid Ethyl Ester for Patients with Cardiovascular Diseases: Differences between Branded (EPADEL®) and Generic Products

  AUTHORS: Michihiro Suwa, Isao Morii, Masaya Kino

  KEYWORDS: Eicosapentaenoic Acid (EPA), Arachidonic Acid (AA), Docosahexaenoic Acid (DHA), Omega-3 Polyunsaturated Fatty Acids, Branded Product, Generic Product

  JOURNAL NAME: Food and Nutrition Sciences, Vol.11 No.10, October 15, 2020

  ABSTRACT: Background: Omega-3 polyunsaturated fatty acids (PUFAs) have some protective benefits for patients with coronary artery and cerebrovascular diseases. Eicosapentaenoic acid (EPA) drugs are prescribed as branded (B: EPADEL?) or generic products but no data exist concerning the differences in treatment outcomes between these products. Methods and Results: We investigated the differences in the serum levels of EPA, docosahexaenoic acid (DHA) and arachidonic acid (AA), and the EPA/AA ratios through blood sampling six months after daily administration of 1800 mg of EPADEL? and a generic EPA drug was initiated for 96 patients with cardiovascular diseases. All patients received these PUFA treatments while continuing with baseline therapy. After 6 months of administration, EPADEL? produced better results than the generic (G) product (EPA; baseline: 59.4 ± 25.5 μg, B: 215.5 ± 58.8 μg, G: 199.7 ± 63.8 μg, B vs G, p μg, B: 158.3 ± 36.3 μg, G: 163.6 ± 38.9 μg, B vs G, p Conclusions: There were clear differences between EPA branded and the generic products. Further study is required to determine whether the benefits from the branded product justify the higher price compared to the generic drug cost.