TITLE:
Immobility Responses Affected by Potassium in Old Rats
AUTHORS:
Linda Garcés-Ramírez, Oscar O. Morales-Dionisio, Gonzalo Flores, José Luna-Muñoz, Fidel de la Cruz
KEYWORDS:
Immobility Responses (IR), Potassium, Spironolactone, Hyperkalemia, Familial Periodic Paralysis
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.11 No.9,
September
30,
2020
ABSTRACT: Four immobility responses (IR): elicited by clamping,
bandaging, grasping and inversion, and their modification by potassium and
spironolactone was studied in old Wistar rats (body weight, 500 g). When undrugged, only
clamping and grasping, but not bandaging and inversion induced an IR in rats.
Potassium and spironolactone significantly enhanced the duration of IR induced
by clamping but not by grasping. They also induced an immobility response by
bandaging, but not by inversion. The data suggest that IR induced by clamping
and bandaging are somehow related to changes in the potassium serum levels. Consequently, such a relationship
may be a suitable model to study some forms of paralysis in human beings which
are related to changes in the potassium serum levels.