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Figueras-Aloy, J., Manzoni, P., Paes, B., Simoes, E.A.F., Bont, L., Checchia, P.A., Fauroux, B. and Carbonell-Estrany, X. (2016) Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection among Preterm Infants without Chronic Lung Disease or Congenital Heart Disease. Infectious Diseases and Therapy, 5, 417-452.
https://doi.org/10.1007/s40121-016-0130-1

has been cited by the following article:

• TITLE: Sero-Epidemiological Study of Respiratory Syncytial Virus

  AUTHORS: Mami Niida, Tetsuo Nakayama, Eitaro Suzuki

  KEYWORDS: RSV, Sero-Epidemiology, Neutralizing Antibody, IgG Enzyme Immunoassay

  JOURNAL NAME: Open Journal of Pediatrics, Vol.10 No.3, September 25, 2020

  ABSTRACT: Background: Respiratory syncytial virus (RSV) is one of the major viruses that cause respiratory infections in all generations, not only in neonates and infants. There is a limited number of reports on serological epidemiology of RSV subgroups A and B. Neutralizing test (NT) antibody reflects protective immunity but bothersome. Sero-epidemiological study should be performed using practical NT method. Methods: Two wild-type viruses subgroups A and B, isolated in 2013, and the Long strain was used as the challenge viruses. NT antibody with 100% inhibition of cytopathic effect (CPE) was examined. A total of 91 serum samples obtained from 0 to 12 years subjects without RSV infection who visited our hospital with some health problems and 121 sera obtained from healthy subjects in different age groups were used. Serological epidemiology of subgroups A and B was investigated in this study using new NT methods. Results: 1) A simple and practical NT method was developed. 2) The NT antibody titer was lowest in × 21.70 ± 2.03 against subgroup A and 5 × 20.85 ± 1.31 against subgroup B) and increased in 3 years of age or older, and high antibody titers were maintained during school age. 3) A slight difference was observed in the NT antibody titers against subgroups A and Bin young children Conclusions: A simple NT assay method was developed in the present study. By the age of 3 years, high NT antibody titers were observed and maintained until 12 years. The IgG (EIA) values decreased with age. No association was observed between IgG (EIA) and NT titers.