TITLE:
Magnetic Resonance Spectroscopy and Prognostic Analysis of Molecular Subtypes of Medulloblastoma
AUTHORS:
Yuting Zhang, Lusheng Li
KEYWORDS:
Medulloblastoma, Molecular Subtypes, MRS, 5-Year EFS
JOURNAL NAME:
Open Journal of Clinical Diagnostics,
Vol.10 No.3,
September
25,
2020
ABSTRACT: Aim: The aim of this study was to investigate whether magnetic resonance
spectrum (MRS) and MR imaging features can be used for non-invasive
medulloblastoma subgrouping, and analyse patient characteristics and prognosis
of molecular subtypes of medulloblastoma. Material and Methods: 32
patients with medulloblastoma underwent MRI prior to surgical resection, 16 of
them underwent MRS. MR imaging features and metabolites measured by MRS were
analysed to distinguish molecular subtypes of medulloblastoma. Patient demographics,
histopathological types, and prognosis of different molecular subtypes were
analysed and compared respectively. Results: MRS and MR imaging features differed from different individuals,
but without statistical significance that involves acquiring non-quantitative
MR imaging features and NAA/Cr, Cho/Cr, Lip/Cr, Glu and Gln/Cr ratio, to be
used to determine molecular subtypes. There was no significant difference of
the three molecular subtypes in age, gender and pathological type. The 5-year
event-free survival (EFS) of SHH, WNT and non SHH/WNT subtype respectively were
75%, 57.1%, 38.1%, with no significant difference (p = 0.382). 5-year
EFS of non SHH/WNT subtype was significantly higher in ≤3 years old group than
>3 years old group (p = 0.047). Conclusion: MRS and MR imaging
features can’t be used to determine molecular subtypes based on our small
sample study. There was no significant difference of the prognosis in the three
molecular subtypes. The prognosis of ≤3 years old group of non SHH/WNT subtype
is better than >3 years old group.