TITLE:
Trypanosoma evansi: A Qualitative and Quantitative Ultrastructural Analysis of the Spleen during Experimental Murine Infections
AUTHORS:
Lucia Proietti d’Empaire, Félix Tejero, Hector J. Finol, Pedro M. Aso, Antonio Roschman-Gonzalez
KEYWORDS:
Trypanosoma evansi, Spleen, Ultrastructure, Mouse
JOURNAL NAME:
Microscopy Research,
Vol.8 No.3,
July
30,
2020
ABSTRACT: A murine
model is used to study qualitatively and quantitatively the splenic ultrastructural
changes induced by two Trypanosoma evansi strains derived from naturally
infected local equine hosts (Equusasinus and E. caballus); T. evansi causes ultrastructural modifications in the spleen of
the infected mice. The modifications include tissular disorganization, fibrosis,
mitochondrial swelling, apoptosis and necrosis. The initial phases of the infection
are quite similar, whereas the final phases differ qualitatively depending on the
strain’s source.
The ultrastructural quantitative changes were studied in the reticular splenocytes
covering alterations in the area of the cytoplasm and nucleus. Analysis of the
results shows the
induction of various splenic
alterations caused by local T. evansi strains. Also, it was documented that discriminative time modulation, as well
as progressive tissular, cellular and subcellular changes, are more associated
with derived infections from E. caballus strain.