TITLE:
Serum Levels of Reproductive Hormones and Their Relationship with Age in Men with Benign Prostatic Hyperplasia in Benin City, Edo State
AUTHORS:
Babatunde Ishola Gabriel Adejumo, Omolei Lilian Williams, Efosa Bolaji Odigie, Ifeoma Gloria Unachukwu, Oladimeji Nasiru Abdulrahman, Uchechukwu Dimkpa, Simon Uzor, Oyarazi Margaret Adebowale, Ojo Moses Oke
KEYWORDS:
Hormones, Age, Men, Prostate, Hyperplasia
JOURNAL NAME:
Health,
Vol.12 No.9,
September
14,
2020
ABSTRACT: Background: Benign Prostatic Hyperplasia (BPH) is a common condition which occurs as men get older. Aim: We aimed at investigating the reproductive hormone profile of men with BPH and the relationship of these hormones with age. Methods: Twenty-nine men of age > 40 years were screened for prostate symptoms. The prostate examination included digital rectal examination and measurement of serum prostate-specific antigen levels. Demographic and clinical characteristics of subjects were obtained using a structured questionnaire. The serum levels of Testosterone (Te), Luteinizing hormone (LH), Follicle stimulating hormone (FSH) and Prolactin (PRL) were measured using ELISA method. Results: Our study indicated that age and levels of prostate specific antigen (PSA), LH and FSH were significantly (p Conclusion: This study suggests that the rise in serum levels of the hypothalamic-pituitary-testicular axis hormones in BPH patients as demonstrated by the present findings may be age-related since testicular dysfunction in aging men is associated with the decrease in androgen production which may stimulate an increased production of gonadotropins by negative feedback.