TITLE:
Purine and Pyrimidine-Linked Enzymes and Genes are Strongly Responsible for the Development of Tumors, Particularly Glioblastoma Multiforme
AUTHORS:
Kristine Edgar Danielyan, Tatul Ashot Yeghiazaryan, Samvel Grigoriy Chailyan, Levon Ruben Harutyunyan, Ruben Levon Harutyunyan, Gurgen Sergei Petrosyan
KEYWORDS:
Data Bases, Purine, Pyrimidine, Metabolism, Glioblastoma, PRPS1
JOURNAL NAME:
Computational Molecular Bioscience,
Vol.10 No.3,
September
8,
2020
ABSTRACT: We were aiming to delineate, by the utility of the biological data results, in our investigations the link between the purine and pyrimidine metabolism and development of the glioblastoma. We analyzed the sets of the genes, belonging to the purine and pyrimidine metabolism by the utility of GSEA software as well as MSIgnDB application of the GSEA. The GEO database, GEOR2 tools were serving for the visualization of the genes expression profiles of the disease. The Cancer Proteome Atlas as well as the tools of the data sets were also used to collect and analyze the results. We concluded and came to the following consequential results. 1) Neurogenesis and Glioblastoma are sharing some common genes. 2) Purine and pyrimidine metabolism-linked enzymes and genes are responsible for the upregulation of DNA and mRNA synthesis in the settings of the tumor development. 3) EGFR expression responsible genes, mRNA as well as protein is upregulated during the development of the glioblastoma. 4) GMPS genes are more strongly upregulated in the settings of the glioblastoma than ADSL. 5) PRPS1 is strongly synthetized in neurospheres in contrast to the mature tissue during glioblastoma development.