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Hitt, S., Sangeeta, Y., Sanjay, L., Subliash, K., Suresh, J., Sameer, P., et al. (2013) Antibody Persistence of Two Pentavalent DTwP-HB-Hib Vaccine to Age of 15-18 Months and Response to the Booster Dose of Quadrilateral DTwP-Hib Vaccine. Vaccine, 31, 444-447.
https://doi.org/10.1016/j.vaccine.2012.11.038

has been cited by the following article:

• TITLE: Comparative Pertussis Antibody Response of Nigerian Children to Diphtheria, Pertussis, Tetanus (DPT) and Pentavalent Vaccines

  AUTHORS: Emmanuel Eyo Ekanem, Glory Ekpo Bassey, Henry Chima Okpara, Eyong Komomo Ibor

  KEYWORDS: Anti-Pertussis Immunoglobulin G, Diphtheria-Pertussis-Tetanus, Pentavalent Vaccine, Comparative

  JOURNAL NAME: World Journal of Vaccines, Vol.10 No.3, August 31, 2020

  ABSTRACT: Background: In Nigeria Pentavalent vaccine had replaced Diphtheria-Pertussis- Tetanus [DPT] vaccine in the prevention of pertussis since 2012. Aims and Objectives: The aim of this study was to compare the anti-pertussis immunoglobin G (IgG) response of children who received DPT with those who received the pentavalent vaccine. Subjects and Methods: This study was carried out in Akpabuyo LGA of Cross River State from April to June 2016. It was a cross-sectional survey of anti-pertussis IgG levels in children aged 6 months to 5 years who received DPT and those who received pentavalent vaccine. IgG antibody levels were determined using enzyme-linked immunosorbent assay. The protective level was set at >11 DU according to manufacturer’s cut off point. Results: Seventy eight out of 230 children [33.9%] who had received DPT had protective levels of anti-pertussis IgG compared to 74 out of 192 children [38.5%] who had received pentavalent vaccine. The difference was not statistically significant [p = 0.61]. The median IgG antibody level in those who received DPT was 8.0 DU (interquartile range (IQR) 4.0 - 13.0) compared with 9.0 DU (IQR) 4.0 - 15.0 in those who received pentavalent vaccine [p = 0.18]. No single factor investigated predicted the development of protective levels of antibody in the multivariate analysis. Conclusion/Recommendation: There was no difference in the antipertussis antibody response between DPT and pentavalent vaccines recipients. Further study is needed to elucidate factors that could be responsible for low anti-pertussis antibody response in this population.