TITLE:
A Simultaneous Multidisciplinary Evaluation of Irritable Bowel Syndrome in Egyptian Patients: Dietary, Psychiatric, Microbiologic and Autonomic Aspects
AUTHORS:
M. Abdelbary, A. Al-Sayyad, M. Menesy, M. Nasreldin, R. Mostafa, A. Nawito, R. Marzaban
KEYWORDS:
Irritable Bowel Syndrome (IBS), Eysenck Personality Questionnaire (EPQ), Hopkins Symptom Checklist (HSCL-90), Microbiota, Autonomic Activity
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.10 No.8,
August
27,
2020
ABSTRACT: Background and Aim: Irritable bowel syndrome (IBS) is a common medical disorder that may be
severe enough to impair the quality of life. This study aimed to assess the
role of each of dietary, psychiatric, autonomic, and microbiology background and their
interactions in Egyptian patients with IBS. Patients and Methods: Forty
adult patients diagnosed with IBS, equally divided into 2 groups the diarrhea
predominant and the constipation predominant, were recruited from the Endoscopy
Unit. Dietary assessment was done by monthly food frequency questionnaire.
Psychiatric assessment was done by both the Eysenck Personality Questionnaire
(EPQ) and Hopkins Symptom Checklist (HSCL-90). Microbiologic evaluation was
done by faecal cultures and neurophysiologic autonomic evaluation was done via
the sympathetic skin response and the parasympathetic R-R interval variation. Another
20 healthy subjects were included as control group. Results: All IBS
patients were young, with significant female predominance (P = 0.007), particularly in IBS-C group (20/20; 100%, P = 0.003). Psychologically, abnormal scores of
neuroticism, extraversion and criminality, and depression, obsessive
compulsion, somatization, sensitivity and anxiety in both IBS groups with
particularly extraversion, criminality and depression were significantly higher
in constipation subtype. Microbiologically, Bacteroids were significantly related to IBS, while Klebsiella
was significantly deficient without significant difference between its groups.
On the contrary, neither diet nor autonomic activity showed any significant
relation. Conclusions: IBS is a disorder induced by many factors and affected
by several interacting agents, thus revealing controversial results when studied
simultaneously.