TITLE:
The Role of HER2/Neu and BRCA1 Genes in the Diagnosis of Breast Cancer among Sudanese Women
AUTHORS:
Mohamed Ahmed Osman, Faris Merghani Eltom, Mohamed Elzubier Abdallah, Saad Ali S. Aljohani
KEYWORDS:
HER2/Neu and BRCA1 Genes, Breast Cancer, Sudan
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.8,
August
24,
2020
ABSTRACT: Background: Knowledge of HER2/Neu and BRCA1 Genes might be helpful for development of
strategies for decreasing the burden of risk of breast cancer. Therefore, the
aim of this study to detect the role of HER2/Neu and BRCA1 Genes expression in
diagnosis of breast cancer in Sudanese women. Methodology: A total of
100 tissue samples obtained from patients with breast cancer in addition to 50
tissue samples obtained from patients with benign breast lesions, were detected
the expression of HER2/Neu and BRCA1 Genes by Polymerase Chain Reaction (PCR). Results: The prevalence of HER2/Neu and BRCA1 Genes, among cases was 6%,
and 10% respectively. Conclusion: HER2/Neu and BRCA1 Genes have a considerable contribution to etiology of breast
cancer in Sudan that requires further consideration.