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Rodriguez, F.J., Gamez, J.D., Vrana, J.A., Theis, J.D., Giannini, C., Scheithauer, B.W., Parisi, J.E., Lucchinetti, C.F., Pendlebury, W.W., Bergen, H.R. 3rd and Dogan, A. (2008) Immunoglobulin Derived Depositions in the Nervous System: Novel Mass Spectrometry Application for Protein Characterization in Formalin-Fixed Tissues. Laboratory Investigation, 88, 1024-1037.
https://doi.org/10.1038/labinvest.2008.72

has been cited by the following article:

• TITLE: Brain Amyloidoma: Case Report and Literature Review

  AUTHORS: Abd El Kader Moumouni, Daniel Memia Zolo, Essossinam Kpelao, Pascal Compaore, Dabou Abiba Tamou Tabe, Latevi Lawson, Pwerew Rodolphe Plante, Edem Kossi Gueouguede, Benedicte Souho, Abderrahmane Hamlat

  KEYWORDS: Amyloidoma, Brain, Literature Review

  JOURNAL NAME: Open Journal of Modern Neurosurgery, Vol.10 No.4, August 24, 2020

  ABSTRACT: Introduction: Primary deposition of amyloid can take several forms including amyloidoma organ restricted among which is brain. Brain amyloidoma can mimic several lesions and offers a diagnostic challenge to the physician. The present work reports an additional case and summarizes the salient characteristics of previously published cases. Case Report: A 61-year-old, woman experienced paroxystic auditory hallucinations followed at times by generalized tonico-clonic seizures. Examination revealed a mild left pyramidal weakness. Head CT scan and MRI revealed a lobular lesion of the right atrium with contrast enhancement. The diagnosis of amyloidoma Lambda light chain (λLC) type was performed by means of a stereotactic biopsy. The patient was treated by 3 cures of high dose methotrexate (15 mg/m2). At 24 months follow up the patient remains stable clinically and biologically. The 2 years follow-up MRI showed the same findings. Conclusion: No guidelines can be suggested for brain amyloidoma treatment; the “wait and see” was the mind-set in the literature. However, a non-tumour like pattern of a cerebral mass developing near the ventricle with a fine, irregular radiating margin enhancement and lack of oedema, and mass effect are important MRI clues for brain amyloidoma diagnosis. The diagnosis is histological after biopsy or excision.