TITLE:
Sedative effects of peanut (Arachis hypogaea L.) leaf aqueous extracts on brain ATP, AMP, Adenosine and Glutamate/GABA of rats
AUTHORS:
Xiao-Yan Zu, Zhen-Ya Zhang, Ji-Qiang Liu, Hong-Hai Hu, Guo-Qing Xing, Ying Zhang, Di Guan
KEYWORDS:
Arachis Hypogaea L. Leaf Aqueous Extracts; Sedative Effects; Rats; Neurotransmitters
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.3 No.3,
April
9,
2010
ABSTRACT: Peanut (Arachis hypogaea L.) leaf aqueous extracts (PLAE) has been reputed to be a type of sleep-aid in China. To investigate the sedative effects and effect pathways of PLAE, rats (n = 31) were employed in two experiments and intragastrically administrated of (1) distilled water, PLAE (500 mg/kg body weight (BW)) and peanut stem aqueous extracts (PSAE, 500 mg/kg BW); (2) 0, 100 or 500 mg/kg BW of PLAE, respectively for at least 14 days. Six relevant neurotransmitters were measured finally. Experiment-1 (n = 16) results showed that the brain Lactate were significantly elevated (p