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Wigren, H.K., Schepens, M., Matto, V., Stenberg, D. and Porkka-Heiskanen, T. (2007) Glutamatergic stimulation of the basal forebrain elevates extracellular adenosine and increases the subsequent sleep. Neuroscience, 147, 811-823.

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• TITLE: Sedative effects of peanut (Arachis hypogaea L.) leaf aqueous extracts on brain ATP, AMP, Adenosine and Glutamate/GABA of rats

  AUTHORS: Xiao-Yan Zu, Zhen-Ya Zhang, Ji-Qiang Liu, Hong-Hai Hu, Guo-Qing Xing, Ying Zhang, Di Guan

  KEYWORDS: Arachis Hypogaea L. Leaf Aqueous Extracts; Sedative Effects; Rats; Neurotransmitters

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.3 No.3, April 9, 2010

  ABSTRACT: Peanut (Arachis hypogaea L.) leaf aqueous extracts (PLAE) has been reputed to be a type of sleep-aid in China. To investigate the sedative effects and effect pathways of PLAE, rats (n = 31) were employed in two experiments and intragastrically administrated of (1) distilled water, PLAE (500 mg/kg body weight (BW)) and peanut stem aqueous extracts (PSAE, 500 mg/kg BW); (2) 0, 100 or 500 mg/kg BW of PLAE, respectively for at least 14 days. Six relevant neurotransmitters were measured finally. Experiment-1 (n = 16) results showed that the brain Lactate were significantly elevated (p