TITLE:
Physical Exercise and Gene p53—A Mini Review
AUTHORS:
Tayane Horstmann Cabral, Ana Luiza Lozinski, Gabriel Massao Tanaka, Marco André Cardoso, Rossana Baggio Simeoni, Péricles Varella Gomes, Zair Candido Oliveira Netto, Luiz Cesar Guarita-Souza, Julio Cesar Francisco, Ricardo Correa Cunha
KEYWORDS:
p53, Physical Exercise, Gene Mutations, Autophagy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.11 No.8,
August
18,
2020
ABSTRACT: Cancer is a global problem that in addition to physical, emotional and physiological causes
economic and social impacts. The p53 gene is a tumor suppressor gene found in
many malignant and benign tumors; this has the primary function of keeping
cells at rest after damaging to DNA. The p53 acts in the maintenance of
cellular homeostasis, mainly through autophagy, playing a role in cell cycle
arrest, when necessary, thus avoiding mutated DNA replication. When in the
oncogenic environment in many cases it is mutated, losing much of its
efficiency allowing tumor development. Studies show that exercise can in the
regular part of its pro-autophagic function even in the oncology setting.
Stimuli of moderate-intensity aerobic and predominance of submaximal seem to
trigger the protective function of p53 in various cancer settings. Among the
many changes that these pathology triggers were the objective of this mini
review is to relate the changes that exercise generates in p53 protein
functions and their possible influence on tumor cells.