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Maslowski, K.M., Vieira, A.T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H.C., Rolph, M.S., Mackay, F. and Artis, D. (2009) Regulation of Inflammatory Responses by Gut Microbiota and Chemoattractant Receptor GPR43. Nature, 461, 1282-1286.
https://doi.org/10.1038/nature08530

has been cited by the following article:

• TITLE: Oleic acid Stimulates the Formation of Adipocyte-Like Cells from Bovine Satellite Cells via G-Protein Coupled Receptor 43 and CCAAT/Enhancer-Binding Protein Beta

  AUTHORS: J. Kim, K. Chung, L. K. Fuerniss, B. J. Johnson

  KEYWORDS: Bovine Satellite Cells, GPR43, Intramuscular Adipose Tissue, Oleic Acid

  JOURNAL NAME: Open Journal of Animal Sciences, Vol.10 No.4, August 17, 2020

  ABSTRACT: Numerous physiological and pathological processes are controlled by free fatty acids, which act as signaling molecules in mammals. We hypothesized that oleic acid (Ole) might stimulate the formation of satellite-cell-derived intramuscular adipose tissue. The role of Ole as a ligand of G-protein-coupled receptor 43 (GPR43) was previously identified. Thus, the objective of the current study was to determine the effect of Ole on GPR43 and factors related to the adipogenic differentiation of bovine satellite cells (BSC). Treatments of 100 μM and 500 μM Ole tended to induce greater (P CCAAT/enhancer-binding protein β (C/EBPβ) compared to all other doses. The mRNA abundance of peroxisome proliferator-activated receptor γ (PPARγ) was not altered (P > 0.10) by treatment. The addition of 100 μM and 500 μM of Ole upregulated (P GPR43 mRNA expression. Protein level of GPR43 was increased (P C/EBPβ in response to Ole might suppress myogenic differentiation. After the treatment of cells with Ole, increased expression of GPR43 could lead to phosphorylation of 5’ AMP-activated protein kinase α (AMPKα). Altogether, the results indicated that increased Ole might stimulate adipose tissue accumulation within the skeletal muscle of cattle by promoting adipogenic differentiation and activation of GPR43 in satellite cells.