Article citationsMore>>

Ozyigit, G., Hurmuz, P., Sari, S.Y., Yazici, G. and Gultekin, M. (2016) Target Volume Delineation Guidelines in Malignant Pleural Mesothelioma. In: Ozyigit, G., Selek, U. and Topkan, E., Eds., Principles and Practice of Radiotherapy Techniques in Thoracic Malignancies, Springer, Cham, Chapter 19, 433-440.
https://doi.org/10.1007/978-3-319-28761-4_19

has been cited by the following article:

• TITLE: Complex Target Volume Delineation and Treatment Planning in Radiotherapy for Malignant Pleural Mesothelioma (MPM)

  AUTHORS: Aaron Innocent Bogmis, Adrian Raducu Popa, Daniela Adam, Violeta Ciocâltei, Nicoleta Alina Guraliuc, Florin Ciubotaru, Ion-Christian Chiricuță

  KEYWORDS: Malignant Pleural Mesothelioma, Radiation Therapy, Radiotherapy, Volumetric Modulated Arc Therapy, VMAT, Target Volume Delineation, Treatment Planning, CTV, PTV

  JOURNAL NAME: International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, Vol.9 No.3, August 17, 2020

  ABSTRACT: Introduction: Radiotherapy alone or combined with surgery and/or chemotherapy is being investigated in the treatment of malignant pleural mesothelioma (MPM). This study aimed to simulate a Volumetric Modulated Arc Therapy (VMAT) treatment of a patient with MPM. Materials and Methods: CT images from a patient with intact lungs were imported via DICOM into the Pinnacle3 treatment planning (TP) system (TPS) and used as a model for MPM to delineate organs at risk (OAR) and both clinical and planning target volumes (CTV and PTV) with a margin of 5 mm. Elekta Synergy with 6 MV photons and 80 leafs MLCi2 was employed. VMAT plans were generated using two coplanar arcs with gantry rotation angles of 178° - 182°, the collimator angles of each arc were set to 90°, Octavius® 4D 729 was employed for quality assurance while the calculated and measured doses were compared using VeriSoft. Results: A TP was achieved. The Gamma volume analysis with criteria of 3 mm distance to agreement and 3% dose difference yielded the gamma passing rate = 99.9%. The reference isodose was 42.75 Gy with the coverage constraints for the PTV D95 and V95 = 95.0% of 45 Gy. The remaining dosimetric parameters met the recommendations from the clinically acceptable guidelines for the radiotherapy of MPM. Conclusion: Using well-defined TV and VMAT, a consistent TP compared to similar ones from publications was achieved. We obtained a high agreement between the 3D dose reconstructed and the dose calculated.