TITLE:
Clinical Observation of rhIL-2 Combined with Zhenqi Fuzheng and BaofuKang Suppository in the Treatment of Cervical Intraepithelial Neoplasia II with HPV Infection
AUTHORS:
Yu Cai, Jianjun Zhai, Jinping Xun, Xiaojin He
KEYWORDS:
Cervical Intraepithelial Neoplasia II, Human Papilloma Virus, Recombinant Human Interleukin-2, Zhenqi Fuzheng, Baofukang
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.10 No.8,
August
14,
2020
ABSTRACT: Objective: To
investigate the clinical effects of recombinant human
interleukin-2 (rhIL-2) combined with Zhenqi Fuzheng
and Baofukang on cervical intraepithelial neoplasia II (CINII) combined
with human papilloma virus infection. Methods: There were 593 patients
diagnosed with CINII with HPV infection, including 296 in the control group and
297 in the experimental group. The control group was given only Zhenqi Fuzheng
oral and Baofukang suppository vaginal medicine. The experimental group was
treated with rhIL-2 injection in addition to Zhenqi Fuzheng oral and Baofukang
suppository vaginal medicine which is treated for 3 months. After 3 months, Thinprep
cytologic test (TCT), human papilloma virus (HPV) quantitative examination and
colposcopy biopsy were reviewed. Results: After 3 months of treatment,
the negative conversion rate and total effective rate of HPV in the control
group were 58.11% and 70.95% respectively, and the negative conversion rate and
total effective rate of the experimental group were 79.46% and 90.57%
respectively. There was significant difference between the two groups (p =
0.000). The curative rate of cervical lesions was significantly higher in the
test group than in the control group, 89.56%, 68.91%, respectively. The statistical
difference between the two groups is significant (p = 0.000). Conclusion: It has an essential clinical value that HPV infection patients and cervical intraepithelial
neoplasia II associated with HPV infection patients
are treated by rhIL-2 combined with Zhenqifuzheng and Baofukang, which is safe, effective, non-invasive, reusable
advantages. However, the long-term efficacy and side effects need to be further
studied.