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Knaus, M., Marawan, A., Madi, A., Ibarra-Velarde, F., Dawie, J., Kusi, K.L., Postoli, R., Chester, S.T., Rosentel, J., Alva, R., Irwin, J., Visser, M., Winter, R. and Rehbein, S. (2014) Efficacy of a Novel Topical Fipronil, (S)-Methoprene, Eprinomectin and Praziquantel Combination against Naturally Acquired Intestinal Nematode and Cestode Infections in Cats. Veterinary Parasitology, 202, 18-25.
https://doi.org/10.1016/j.vetpar.2014.02.033

has been cited by the following article:

• TITLE: Additive Efficiency of Fipronil + Methoprene Compared to Fipronil Alone against Rhipicephalus sanguineus Ticks in Naturally Infested Dogs

  AUTHORS: Froylán Ibarra-Velarde, Yolanda Vera-Montenegro, Yazmín Acala-Canto, Irene Cruz-Mendoza

  KEYWORDS: Ticks, Dogs, Efficacy, Fipronil, Fipronil + Methoprene

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.11 No.8, August 14, 2020

  ABSTRACT: The acaricidal efficiency of fipronil alone and fipronil + methoprene compared to commercial fipronil and commercial fipronil + methoprene, applied by the epicutaneous route (spot-on) in dogs naturally infested with ticks, was assessed. Thirty dogs infested with high loads of ticks were used. On day 0, the dogs were divided into 5 groups of 6 animals each. Each animal was duly identified for individual and group monitoring. Treatments were made based on body weight according to manufacturer’s instructions. Group 1 (G1) received 10.0% fipronil at a single dose of a pipette applied by epicutaneous route in the base of the neck. G2 received 10% fipronil + 10% methoprene in single application similarly to G1. G3 was treated with 9.8% commercial fipronil as before mentioned. G4 received commercial 9.8% fipronil + 9.8% methoprene applied as in previous groups. G5 served as an infected untreated control. Animals were examined by thumb tick counts on days 0 (Treatment day), 3, 7, 14, 21 and 28. Efficacy was measured as a percentage of tick reduction in the treated groups relative to the untreated control. Results indicated an overall efficacy of 88.2%, 93%, 90.4% and 99.3%, respectively. There was no significant statistical difference between the treated groups (P ly and in full development. It is concluded that the combined formulations of fipronil + methoprene compared to fipronil applied alone, showed an additive effect against Rhipicephalus sanguineus ticks in naturally infested dogs kept in captivity.