TITLE:
Additive Efficiency of Fipronil + Methoprene Compared to Fipronil Alone against Rhipicephalus sanguineus Ticks in Naturally Infested Dogs
AUTHORS:
Froylán Ibarra-Velarde, Yolanda Vera-Montenegro, Yazmín Acala-Canto, Irene Cruz-Mendoza
KEYWORDS:
Ticks, Dogs, Efficacy, Fipronil, Fipronil + Methoprene
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.11 No.8,
August
14,
2020
ABSTRACT: The acaricidal efficiency of fipronil alone and fipronil
+ methoprene compared to commercial fipronil and commercial fipronil + methoprene,
applied by the epicutaneous route (spot-on) in dogs naturally infested with
ticks, was assessed. Thirty dogs infested with high loads of ticks were used.
On day 0, the dogs were divided into 5 groups of 6 animals each. Each animal
was duly identified for individual and group monitoring. Treatments were made
based on body weight according to manufacturer’s instructions. Group 1 (G1) received 10.0% fipronil
at a single dose of a pipette applied by epicutaneous route in the base of the neck. G2 received 10% fipronil
+ 10% methoprene in single application similarly to G1. G3 was treated with
9.8% commercial fipronil as before mentioned. G4 received commercial 9.8% fipronil
+ 9.8% methoprene applied as in previous groups. G5 served as an infected
untreated control. Animals were examined by thumb
tick counts on days 0 (Treatment day), 3, 7, 14, 21 and 28. Efficacy was
measured as a percentage of tick reduction in the treated groups relative to
the untreated control. Results indicated an overall efficacy of 88.2%, 93%,
90.4% and 99.3%, respectively. There was no significant statistical difference
between the treated groups (P ly and in full development. It is concluded that the combined formulations
of fipronil + methoprene compared to fipronil applied alone, showed an additive
effect against Rhipicephalus sanguineus ticks
in naturally infested dogs kept in captivity.