TITLE:
Association of NFkB1 Gene Polymorphism with Inflammatory Markers in Patients of Type 2 Diabetes Mellitus with or without Renal Involvement in Eastern India
AUTHORS:
Sonalika Behera, Andrew Abel Lamare, Roma Rattan, Bijan Patnaik, Sidhartha Das
KEYWORDS:
DN: Diabetic Nephropathy, UACR: Urinary Albumin Creatinine Ratio, UMCP1: Urinary Monocyte Chemoattractant Protein 1, TNF Alfa: Tumor Necrosis Factor Alfa, NFkB1: Nuclear Factor Kappa B, Ins/Ins Polymorphism: Insertion/Insertion Polymorphism, Del/Del Polymorphism: Deletion/Deletion Polymorphism, Ins/Del Polymorphism: Insertion/Deletion Polymorphism
JOURNAL NAME:
Journal of Diabetes Mellitus,
Vol.10 No.3,
August
12,
2020
ABSTRACT: Aims: To evaluate the association of Nuclear factor kappa B1(NFkB1) gene polymorphism with inflammatory markers Urinary Monocyte Chemoattractant Protein 1 (UMCP1) and Tumor Necrosis Factor alfa (TNF alfa) in Patients of diabetes mellitus with or without renal involvement in Eastern India. Material and Methods: Consecutive Patients of Type 2 Diabetes Mellitus (DM) with or without microalbuminuria attending SCB MEDICAL COLLEGE and HOSPITAL Medical OPDs in between September 2018 to September 2019 were recruited in this study. Patients were subjected to blood and urine investigations. DNA extraction and Restriction fragment Length Polymorphism (RFLP) was done in Department of Biochemistry. Controls were unrelated healthy attendants with no history of Diabetes Mellitus, HTN, Chronic Kidney Disease (CKD). Results: Mean Systolic BP, Fasting Blood Glucose, Post Prandial Blood Glucose, HBA1c, Total Cholesterol were significantly higher in diabetes mellitus and diabetic nephropathy groups than control group. Estimated Glomerular Filtration Rate was significantly lower in diabetic nephropathy (p value Conclusion: insertion/insertion NFkB1 gene polymorphism increases the risk of nephropathy by 2.52 times (OR = 2.52, 95% CI: 0.04 - 0.63, p value = 0.019) in diabetes patients in eastern India.