TITLE:
An environmentally Benign Synthesis of 2-Cyanomethyl-4-Phenylthiazoles under FocusedMicrowave Irradiation
AUTHORS:
Todor Deligeorgiev, Stefka Kaloyanova, Nedyalko Lesev, Ramón Alajarín, Juan J. Vaquero, Julio Álvarez-Builla
KEYWORDS:
2-Cyanomethyl-4-Phenylthiazoles, Microwave Synthesis, Glycerol, Green Chemistry
JOURNAL NAME:
Green and Sustainable Chemistry,
Vol.1 No.4,
November
16,
2011
ABSTRACT: An improved environmentally benign procedure for synthesis of substituted 2-cyanomethyl-4-phenylthia- zoles under focused microwave irradiation using glycerol as solvent has been carried out. The method allows the synthesis of products in excellent yields with short reaction times and the work-up is easy. This approach can be applied to the preparation of a variety of derivatives.