TITLE:
Phytochemical Screening and Acute Toxicity Evaluation of Leaves Extract of Two Fabaceae’s Species: Sesbania pachycarpa DC. and Indigofera berhautiana Gillett
AUTHORS:
Monique Brigitte Ouattara, Jean Hubert Bationo, Martin Kiendrebeogo, Odile Germaine Nacoulma
KEYWORDS:
Sesbania pachycarpa DC., Indigofera bergautiana Gillet, Aqueous Extracts, Acute General Toxicity, NMRI Strain, Phytochemicals Compounds
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.8 No.7,
July
17,
2020
ABSTRACT: Objective: The aim of this study is to screen chemical composition and to evaluate the acute general toxicity of leaves aqueous extracts from Sesbania pachycarpa DC. (Fabaceae), used in traditional medicine in Burkina Faso to treat malaria, helminthiasis, and aqueous extracts of the leaves from Indigofera berhautiana Gillet (Fabaceae) used to treat hepatitis and typhoid fever. Methods: Aqueous decoction of leaves from Sesbania pachycarpa DC. or Indigofera berhautiana Gillett which are the form of use recommended by traditional health practitioners, were used for tests. Aqueous extracts used to evaluate the acute toxicity, were studied on mice of strain NMRI. For the toxicity study, the doses of the aqueous extracts were respectively 5 mg/kg, 50 mg/kg, 300 mg/kg and 2000 mg/kg of body weight. Phytochemical screening was done to identify the phytochemicals contained in extracts. Results: Aqueous extracts of two species: Sesbania pachycarpa DC., Indigofera berhautiana Gillet were not toxic at the maximum dose of 2000 mg/kg of body weight. Phytochemical screening, showed coumarins, flavonoids, tannins, polyphenols compounds, steroids and/or triterpenes and saponosides in the aqueous extracts of the two species. Alkaloids were identified in Sesbania pachycarpa aqueous extract.