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Daviglus, M.L., Bell, C.C., Berrettini, W., Bowen, P.E., Connolly, E.S., Cox, N.J. and Trevisan, M. (2010) NIH State-of-the-Science Conference Statement: Preventing Alzheimer’s Disease and Cognitive Decline. NIH Consensus and State-of-the-Science Statements, 27, 1-30.

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• TITLE: Effects of Chewing Frequency on Cerebral Blood Flow and Cognitive Function

  AUTHORS: Saya Natsui, Megumi Sato, Tomomi Yokoyama, Hiromi Inaba, Naomi Kuboyama, Kenichi Shibuya

  KEYWORDS: Mastication, Frequency, Brain Activity, Uchida-Kraepelin Test, Near-Infrared Spectroscopy

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.10 No.7, July 16, 2020

  ABSTRACT: The purpose of the present study was to examine the effect of the frequency of mastication on cerebral activation and task scores for computational tasks. Eleven healthy subjects participated in the present study (nine women, two men). Subjects carried out the Uchida-Kraepelin Test for 15 min before and after chewing tasteless gum for five minutes. The oxygenation of the left prefrontal cortex was monitored by near-infrared spectroscopy during the computational tasks. Task scores did not differ significantly according to chewing frequency (p > 0.05). Conversely, the oxygenation value measured after mastication at a chewing frequency of 110 times/minute (Hz) was significantly higher than that observed before mastication (p 0.05 for both). The results of the present study suggest that tasteless mastication does not enhance calculation performance, while a high mastication frequency demonstrates an influence on oxygenation. However, our study indicates that chewing tasteless gum per se does not increase cognitive performance.