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C. van Haaften, C. C. Duke, A. M. Weerheim, N. P. M. Smit, P. M. M. van Haard, F. Darroudi and B. J. M. Z. Trimbos, “Potent Cytotoxic Effects of Calomeria Amaranthoides on Ovarian Cancers,” Journal of Experimental & Clinical Cancer Research, Vol. 30, No. 1, 2011, p. 29. doi:10.1186/1756-9966-30-29

has been cited by the following article:

• TITLE: Efficient Isolation of an Anti-Cancer Sesquiterpene Lactone from Calomeria amaranthoides by Steam Distillation

  AUTHORS: Colin Charles Duke, Caroline van Haaften, Van Hoan Tran

  KEYWORDS: Sesquiterpene Lactone, Calomeria amaranthoides, Steam Distillation, Chromatography

  JOURNAL NAME: Green and Sustainable Chemistry, Vol.1 No.4, November 16, 2011

  ABSTRACT: An efficient method of isolating an anti-cancer sesquiterpene lactone, eremophila-1(10)-11(13)-dien-12,8?- olide, was developed from fresh Calomeria amaranthoides plant material on the basis of its non-polar vola-tile property. Steam distillation of fresh plant material gave a high recovery of sesquiterpene-rich oil, 0.56%, compared with the estimated 0.66% calculated from solvent extraction of dried plant material. The ses-quiterpene-rich oil containing 58% of the sesquiterpene lactone was fractionated by the short-column vac-uum chromatography method, using minimal stationary-phase and solvent, to give the sesquiterpene lactone 95% purity, yield 41%.