TITLE:
In Situ Characterization of Lopinavir by ATR-FTIR Biospectroscopy
AUTHORS:
Alireza Heidari
KEYWORDS:
ATR-FTIR Biospectroscopy, Simulation, Lopinavir, Breakdown, Coronavirus Disease-2019, COVID-19, Infection, Protective and Therapeutic Effect, Potent Drug
JOURNAL NAME:
Computational Chemistry,
Vol.8 No.3,
July
14,
2020
ABSTRACT: Lopinavir is an antiretroviral of the protease inhibitor class (Figure 1 and Figure 2). It is used against HIV infections as a fixed-dose combination with another protease inhibitor, ritonavir (lopinavir/ritonavir). In the current research, the stimulated ATR-FTIR biospectroscopy of liquid sample of Lopinavir was investigated. The stimulated ATR-FTIR diffractions emitted through focusing the second harmonic laser beam Nd:YAG into the sample were recorded by Echelle spectrometer and ICCD detector. Increasing the energy of laser beam from 2.6 (mJ) to 16 (mJ) led to increase in stimulated ATR-FTIR signal but after breakdown threshold of liquid sample, further increasing energy led to the decrease in stimulating ATR-FTIR signals and for energies higher than 20 (mJ), they were disappeared.