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Seo, Y.S., Park, S.Y., Kim, M.Y., Kim, J.H., Park, J.Y., Yim, H.J., Jang, B.K., Kim, H.S., Hahn, T., Kim, B.I., Heo, J., An, H., Tak, W.Y., Baik, S.K., Han, K.H., Hwang, J.S., Park, S.H., Cho, M. and Um, S.H. (2014) Lack of Difference among Terlipressin, Somatostatin and Octreotide in the Control of Acute Gastroesophageal Variceal Hemorrhage. Hepatology, 60, 954-963.
https://doi.org/10.1002/hep.27006

has been cited by the following article:

• TITLE: Ectopic Ascending Colonic Variceal Bleeding Treated with Balloon-Occluded Retrograde Transvenous Obliteration in a Decompensated Liver Cirrhosis Patient—A Hepatology Perspective

  AUTHORS: Gim Hin Ho​, Suresh Babu, Chern Hao Chong, Constantinos P. Anastassiades

  KEYWORDS: Ectopic Varices, Colonic Varices, Portal Hypertension, Balloon-Occluded Retrograde Transvenous Obliteration, Sclerotherapy, Liver Cirrhosis

  JOURNAL NAME: Case Reports in Clinical Medicine, Vol.9 No.7, July 13, 2020

  ABSTRACT: Ectopic colonic varices development from liver cirrhosis and portal hypertension is uncommon. They are part of the spectrum of portal hypertensive colopathy. Colonic variceal bleeding remains a rare cause of lower gastrointestinal tract (GI) bleeding. Due to the paucity of cases, there are no well-established conventional treatments for bleeding colonic varices. Different treatments have been reported. Here, we report a case of a 55-year-old gentleman, with a history of alcoholic liver cirrhosis, presenting with severe lower GI bleeding and symptomatic anaemia. An esophagogastroduodenoscopy revealed large esophageal varices with high-risk bleeding stigmata requiring endoscopic variceal ligation. A cross-sectional computed tomography scan showed colonic portosystemic shunts. In light of this and that the severe lower GI bleeding seemed out of proportion to the esophageal varices seen on upper endoscopy, an urgent unprepped colonoscopy was performed which revealed possible bleeding diverticula disease which required endoscopic mechanical hemoclip therapy. However, despite this, patient had recurrence of lower GI bleeding prompting a second colonoscopy. This relook colonoscopy showed ectopic ascending colon varices with high-risk bleeding stigmata. High-dose intravenous vasoactive agent somatostatin (500 mcg/hour) and subsequently terlipressin (2 mg every 4 hours) were used. The patient subsequently underwent successful balloon-occluded retrograde transvenous obliteration (B-RTO) and sclerotherapy. The non-selective beta-blocker (NSBB) carvedilol was started and bridged together with the vasoactive agent until stabilisation of portal hypertension. This difficult case illustrates the dynamic nature of portal hypertensive bleeding. It also highlights the presence of confounding non-variceal pathology complicating diagnosis of portal hypertensive colonic variceal bleeding, and that ectopic ascending colonic variceal bleeding can be treated successfully with B-RTO and sclerotherapy, with meticulous titration of high-dose vasoactive agents and NSBB, in a decompensated alcoholic liver cirrhosis patient.