TITLE:
Baccaurea ramiflora: Isolation of Aldehydes and in Vitro Biological Investigations
AUTHORS:
Sangita Debnath Puja, Choudhury Mahmood Hasan, Monira Ahsan
KEYWORDS:
Baccaurea ramiflora, Aldehyde, NMR Spectroscopy, Antioxidant, Cytotoxicity
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.11 No.7,
July
13,
2020
ABSTRACT: The stem bark of Baccaurea
ramiflora was studied. Four aldehydes named as 3 methoxy 4 hydroxy-cinnamaldehyde (coniferyl
aldehyde); 3, 4, 5 trimethoxy cinnamaldehyde; 3, 4, 5 trimethoxy benzaldehyde and 3,4 dimethoxy benzaldehyde)
(veratraldehyde) have been isolated and then identified by NMR spectroscopy.
All of them are first time reported for this plant. Here in vitro biological investigations include antioxidant and
cytotoxicity study. Among all fractions, the chloroform soluble fraction exhibited
strong free radical scavenging activity having IC50 value of 12.87 μg/ml
compared to BHT (IC50 value 5.64 μg/ml). On the contrary, aqueous
soluble fraction exhibited most toxicity towards brine shrimp compared with
vincristine sulphate having LC50 value of 1.44 and 0.9258 μg/ml respectively.