TITLE:
Flavonoids from the Leaves of Bridelia stipularis with in Vitro Antioxidant and Cytotoxicity Activity
AUTHORS:
Sangita Debnath Puja, Kazi Ruhullah Shahriar, Choudhury Mahmood Hasan, Monira Ahsan
KEYWORDS:
Bridelia stipularis, Flavonoid, Antioxidant, Cytotoxicity
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.11 No.7,
July
13,
2020
ABSTRACT: Methanolic
extract of the leaves of Bridelia stipularis was studied. From this study, we isolated three
known flavonoids. They were identified as 7-O-methyl luteolin, apigenin and
5, 7, 2’, 5’ tetrahydroxyflavone by NMR spectroscopic studies. All of them are first
time documented for this plant. Different solvent fractions were subjected to in vitro antioxidant and cytotoxicity studies.
Both apigenin and ethyl acetate soluble fraction of Bridelia stipularis showed strong antioxidant activity having IC50 value of 8.005, 8.77 μg/mL respectively. Chloroform soluble fraction of Bridelia stipularis exerted the highest toxicity to brine shrimp
and petroleum ether soluble fraction showed moderate toxicity having LC50 value of 1.05, 1.71 μg/mL respectively.