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Collosa, L., Ludman, T., Bouhassira, D., Baron, R., Dickerson, A., Yarnitsky, D., Freeman, R., Truini, A., Nadine, A., Finnerup, N., Eccleston, C., Kalso, E., Bennett, D., Dworkin, R. and Raja, S.(2017) Neuropathic Pain. Nature Reviews Disease Primers, 3, 17002.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371025/

has been cited by the following article:

• TITLE: A Randomized Longitudinal Double-Blind Clinical Trial on Long-Term Neuropathic Symptomatology Relief & Pain Analgesia

  AUTHORS: Xanya Sofra, Nuris Lampe

  KEYWORDS: Aging, Pain Relief, Diabetes Mellitus, Neuropathy, TENS, Ultra-Low Energy Technologies, Nanotechnology, Limp Amputation, Neuropathic Pain

  JOURNAL NAME: Health, Vol.12 No.7, July 8, 2020

  ABSTRACT: Diabetic neuropathic pain is one of the most difficult to treat with high levels of reoccurrence and a substantial increase with aging. It involves expensive hospitalizations, often resulting in an amputated lower limb. We explored a variety of methods treating neuropathic pain such as low-level laser, monochromatic near-infrared treatment, TENS, acupuncture and pulsed electromagnetic fields that demonstrated inconclusive, limited or temporary pain relief with minor or short-term improvements in mobility. Research conducted by ultra-low energy technologies reports pain relief and reduction of inflammation as a result of anti-oxidant electron donation transforming free radicals into stable molecules. We report the results of a randomized double blind one-year-long longitudinal clinical study on 10 diabetic mellitus (DM) subjects with chronic neuropathy, treated with ultra-low energy nanotechnology who experienced substantial long-term neuropathic pain relief. Importantly, pain analgesia and improvement in neuropathic symptomatology were not age-contingent. This contradicts past research postulating that age-accumulated inflammation and endothelial dysfunction can further exacerbate diabetic neuropathy. Importantly, a method offering age-independent, cost-effective, long-term neuropathic pain relief and increased mobility has major implications in reducing hospitalization time and overall expenses by offering a solution that enhances quality of life.