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Faber, M.T., Sand, F.L., Albieri, V., Norrild, B., Kjaer, S.K. and Verdoodt, F. (2017) Prevalence and Type Distribution of Human Papillomavirus in Squamous Cell Carcinoma and Intraepithelial Neoplasia of the Vulva. International Journal of Cancer, 141, 1161-1169.
https://doi.org/10.1002/ijc.30821

has been cited by the following article:

• TITLE: Correlation between Vulvar Symptoms Stratification and Vulvar Cancer Detection: Prospective Cohort Observational Study

  AUTHORS: Mervat A. Elsersy

  KEYWORDS: Cancer, Vulva, Soreness, Lesion, Bleeding

  JOURNAL NAME: Open Journal of Obstetrics and Gynecology, Vol.10 No.7, July 3, 2020

  ABSTRACT: Background: The incidence of cancer vulva is increasing. 50% of cases are occurring at younger age especially the type related to Human Papilloma Virus infection. Cancer vulva can be prevented. Awareness of cancer vulva is deficient among women and healthcare providers. In this study we looked for a correlation between the most significant vulval symptoms to be associated with cancer vulva in order to educate women and to provide guidance for the health care providers. Methods: 569 women were enrolled in this observational cohort study. The patients were stratified according to their symptoms into 5 groups. Biopsy from the vulva, unless the lesion is obviously benign. Results: Vulvar lesion, as a symptom (mass-ulcer), was significantly associated with detection of vulvar cancer (P ≤ 0.001). 100% of those women presented with vulvar lesions (mass or ulcer) had cancer. Positive predictive value (PPV) of vulvar lesion alone was 1.25% but the probability of detection of a cancer dramatically increased when the lesion was accompanied with bleeding 35.2% or pain 26.9% respectively. Conclusion: Presenting symptoms other than a lesion in the vulva as for example, soreness, irritation or bleeding was rarely associated with detection of cancer.