TITLE:
Synthesis of Some New Bispyrazolidine Derivatives for Biological Interest
AUTHORS:
Eman F. Kirolos, Amal S. Yanni
KEYWORDS:
Bispyrazolidine, Cycloaddition, Antimicrobial Activity
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.10 No.2,
June
30,
2020
ABSTRACT: One pot criss-cross cycloaddition reaction of substituted 2,3-diaz-1,3-butadienes (1) and/or (2) with two equivalents of 2,3-dichloro-1,4-naphthoquinone in presence of dry benzene afforded bisnaphth[2,3-c]pyrazolidinetetrone derivatives (3) & (4). The chemical structure was achieved by elemental and spectral analysis. Biological activity of the synthesized compounds was tested against some micro-organisms, and has shown an interesting fungicidal activity and strongly to remarkable bactericidal activity.