TITLE:
Synthesis, Characterization, and Evaluation of Antitumor Potential in MCF-7 Cells of Ruthenium-Derived Compounds
AUTHORS:
Moraes Fabricio Tarso, Galvão Anderson Dourado, Fortaleza Dário Batista, Amorin Kelly Aparecida da Encarnação, Sousa Claudia Cristina, Honorio-França Adenilda Cristina, França Eduardo Luzia, Costa Daniel Tizo, Santos Wagner Batista
KEYWORDS:
Ruthenium Compounds, Pyridine Ligands, Antitumor Activity, Tryptophan Amino Acid, MCF-7 Cells, Ligand N-Heterocyclic
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.10 No.3,
June
28,
2020
ABSTRACT: To synthesize, characterize and evaluate the antitumor potential derived
from ruthenium compounds was generated in this study, from the precursor K[RuCl4(bipy)]
a route in a simple and reproducible synthesis for a novel compound of
coordinating Ru+3 with bipy and L-trip. The spectroscopic
characterization in the middle infrared
region (FTIR) shows the interactions between Ru-(L-trip), evidenced by the
displacement of the carboxylate ion band for higher energies, and also by the displacements of aliphatic amine
bands, suggesting that bidentate coordination of the L-trip ligand occurred.
Analysis of the results obtained with thermoanalytical techniques showed that
the minimum formula of the compound, [RuCl2(bipy)(L-trip)]1/2H2O.
Evaluation of the antitumor potential
of precursor K[RuCl4(bipy)] showed the toxic effects on MCF-7 cell
line, but did not show selectivity and not reached PBMC cells to the
same extent. The evaluation of the antitumor potential of the newly synthesized
compound, [RuCl2(bipy)(L-trip)], demonstrated that the insertion of
an L-tryptophan molecule into the precursor coordination sphere made it
selective when compared to PBMC cells, for MCF-7 type tumor cells.