TITLE:
Predictors of Recurrence of Hepatocellular Carcinoma after Transarterial Chemoembolization: Role of Hepatocyte Growth Factor
AUTHORS:
Amr Mohamed Zaghloul, Ahmed Sedky, Ali Hussein Mohammed, Samer A. El-Sawy, Ahmed Abd El Rady Ahmed, Emad Eldin Nabil
KEYWORDS:
Hepatocellular Carcinoma, Hepatocyte Growth Factor, Prediction of HCC Recurrence
JOURNAL NAME:
Open Journal of Gastroenterology,
Vol.10 No.6,
June
15,
2020
ABSTRACT: Background: Hepatocellular carcinoma is the
third leading cause of tumor related mortality and develops mostly in patients with chronic liver
disease and liver cirrhosis.
Human hepatocyte growth factor (HGF) is produced in various organs of the body and is characterized as a
multifunctional factor with various biologic activities. Aim: Our
aim was to investigate the predictive factors of recurrence specially the role of HGF in patients with HCC treated with
TACE. Patients and Methods: one hundred HCC patients treated by TACE who achieved
complete response were included and divided into two groups according to disease free survival (DFS) status at
1 year: the non-early recurrence (NER) group (1) and the early recurrence (ER) group (2). Univariate
binary logistic regression analysis for the possible risk factors of recurrence
showed that AFP, multinodularity and HGF level were significant. Conclusion: high AFP, multinodularity and high HGF were
inter-related possible risk factors for 1-year
recurrence of HCC in patients with initial remission following TACE.