TITLE:
Evaluating the Protective and Ameliorative Potential of Unripe Palm Kernel Seeds on Monosodium Glutamate-Induced Uterine Fibroids
AUTHORS:
Orinamhe Godwin Agbadua, Lilian Etinosa Idusogie, Amadi Samuel Chukwuebuka, Chukwu Sunday Nnamdi, Samuel Sylvester
KEYWORDS:
Fibroid, Estrogen, Palm Kernel
JOURNAL NAME:
Open Access Library Journal,
Vol.7 No.6,
June
11,
2020
ABSTRACT: The study investigated the protective and curative effects of unripe palm kernel seeds on monosodium glutamate-induced uterine fibroid in rats. The rats were in eight experimental groups according to the time of administration of the unripe palm kernel seeds: the first four groups investigated protective effects of UPK for 28 days and the last four groups investigated the curative effects of UPK after treatment with MSG for 28 days. MSG was administered to the animals by oral gavage at a dose of 200 mg/kg bd wt and UPK was administered as feed at a dose of 1.14 mg/g bd wt during the period of study. Histopathology studies of the uterus in addition to serum total protein, total cholesterol, estrogen and progesterone levels were determined. Significant increased estrogen and progesterone levels were observed in MSG-treated animals. UPK prevented and also led to the reversal of these biomarkers in this study. MSG also resulted in endometrial epithelium distortion and lamina propria fibrosis with UPK ameliorating the distortion observed in the uterus. These findings suggest that UPK contains bioactive constituents that are useful in preventing and reversing MSG-induced uterine hyperplasia.