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Matsuda, I., Nakamura, J., Ohkouchi, M., Torii, Y., Futani, H., Tsukamoto, Y. and Hirota, S. (2019) Expression of p16 in Nodular Fasciitis: An Implication for Self-Limited and Inflammatory Nature of the Lesion. International Journal of Clinical and Experimental Pathology, 12, 1029-1034.

has been cited by the following article:

• TITLE: Intraarticular Nodular Fasciitis in the Knee Joint with USP6-Gene Rearrangement—A Case Report with Special Attention to Diagnostics of Intraarticular Lesions

  AUTHORS: G. Ulrich Exner, Beata Bode-Lesniewska, Pascal A. Schai

  KEYWORDS: Nodular Fasciitis, Knee, Arthroscopy, Intra-Articular Lesions

  JOURNAL NAME: Open Journal of Orthopedics, Vol.10 No.6, June 8, 2020

  ABSTRACT: Background: Nodular fasciitis (NF) is currently considered a self-limited clonal neoplastic process. It shares the rearrangement of USP6-gene with aneurysmal bone cysts and myositis ossificans. The presented case is of interest as this is a rare site of presentation of NF; so far only few single cases of intraarticular NF have been reported with documented USP6-gene rearrangement. Intraarticular neoplasias of the knee joint are rare; the most frequent being tenosynovial giant cell tumor (TSGCT). Given a nationwide annual incidence rate of 14 for the lower extremity and about 75% affecting the knee joint about 10 new cases involving the knee joint can be expected per 1 million persons/year. All other types of benign neoplasms are comparably rare while malignant intraarticular processes are extremely rare with most of them reported as single case studies. Aim: We report our case to emphasize the importance of preoperative diagnostics including the option of biopsy. Intraarticular malignant processes are extremely rare and frequently are operated on accidently with negative consequences for the patient. Tactics and techniques to treat benign processes depend on the correct pathologic diagnosis. Case presentation: The 38 year old man noticed slowly increasing swelling of his left knee joint after wakeboarding. Because of continuing discomfort 2 months later MRI diagnostic revealed, apart from retropatellar cartilage lesions, a popliteal mass compatible with a Baker cyst. The lesion of interest (later diagnosed as NF) was neither recognized by the radiologist nor the treating clinician. During the following 8 months the patient felt increasing swelling of the knee joint. The repeat MRI documented the crescent intraarticular solid synovial mass in the medial patellofemoral recess without signs of hemosiderin impregnation. A percutaneous sonographically guided 16G needle biopsy was performed. Histologically, bland myofibroblastic proliferation suggestive of nodular fasciitis (NF) was found. The next generation sequencing (NGS) demonstrated the presence of MYH9-USP6 gene fusion, confirming the diagnosis of NF. The lesion was excised under arthroscopic control. At 1 year follow-up the patient is asymptomatic. Conclusion: The case is of interest because of its rare pathology. The decision how to treat was based on pathologic biopsy diagnostics including the USP6-gene rearrangement. In view of similar presentation of the rare malignancies we also want to stress the importance of definitive diagnostics which generally are possible only through biopsy.