TITLE:
Syntheses of Coordination Compounds of 2-Amino-3-Methylbutanoic Acid Their Mixed Ligand Complexes and Antibacterial Activities
AUTHORS:
Temitayo O. Aiyelabola, Iyanuoluwa E. Okunade, Johan H. L. Jordaan, Daniel P. Otto
KEYWORDS:
Coordination Compounds, 2-Amino-3-Methylbutanoic Acid, Mixed Ligand Complexes, Minimum Inhibitory Concentration, 1, 10-Phenantroline, Ethylenediamine
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.10 No.3,
June
4,
2020
ABSTRACT: Coordination
compounds of 2-amino-3-methylbutanoic acid were synthesized with chromium(III)
and oxovanadium(IV) ions. M:L; 1:2. Adducts of these complexes using 1,10-phenantroline
and ethylenediamine were further synthesized, M:L, (1:2). These compounds were
characterized using electronic, infra-red spectrophotometry, magnetic
susceptibility measurement and percentage metal analyses. The zones of
inhibition and minimum inhibitory concentrations of the compounds against eight
microbes were studied. The results obtained indicated an octahedral geometry
for the Cr(III) complexes, indicative of additional coordination of two water
molecules. On the other hand a square pyramid geometry was obtained for the
binary oxovanadium complex and its 1,10-phenantroline adduct. However, for the
oxovanadium ethylenediamine adduct a distorted octahedral geometry was
proposed. The result for the antibacterial studies indicated that both mixed
ligand complexes of 1,10-phenantroline exhibited good antibacterial activity,
and in some cases better activity than the standard, streptomycin.