TITLE:
Differences of Plasma Levels of Tryptophan, Serotonin, 5-Hydroxyindole Acetic Acid, and Kynurenine between Healthy People and Patients of Major Monopolar Depression at Various Age and Gender
AUTHORS:
Hiroi Tomioka, Junichi Masuda, Akikazu Takada, Akira Iwanami
KEYWORDS:
Depression, Monopolar Depression, Bipolar Depression, Tryptophan, Serotonin, 5-Hydroxyindole Acetic Acid, Kynurenine, 3-Hydroxykynurenine, Kynurenic Acid, Anthranilic Acid, Xanthurenic Acid, Indole-3-Acetic Acid, SSRI (Selective Serotonin Reuptake Inhibitor), SNRI (Serotonin Norepinephrine Reuptake Inhibitor)
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.11 No.6,
June
3,
2020
ABSTRACT: Background: It is not well analyzed whether there are
differences in plasma levels of tryptophan (TRP) metabolites between healthy
control people (HC) and patients of major monopolar depression (MMD). Methods: Ultra high-speed liquid chromatography/mass spectrometry has been
used for the simultaneous determination of plasma levels of tryptophan metabolites
in depressive patients. Results: There are no significant differences between plasma levels of TRP between HC
and MMD. Plasma levels of TRP of HC are higher in young men, young women, old
men, and old women in this order. Serotonin (5-HT) levels are higher in MMD
than HC. Plasma levels of 5-HIAA of HC are also higher than those of patients
of MMD. Plasma levels of kynurenine (KYN) of healthy old men and old women are
higher than those of young men and old women. Plasma levels of KYN are higher
in old women and young men of MMD than those of HC. Conclusion: Plasma
levels of 5-HT are higher in patients of MMD than those of HC, which may
suggest that use of drugs inhibiting the 5-HT transportation may increase
plasma levels of 5-HT in MMD.