TITLE:
The Correlation between the Intrinsic and Extrinsic Molecular Markers in the Inhibition of the Lungs Carcinogenesis Growth by Mahkota Dewa Polyphenols on Balb/c Mouse
AUTHORS:
Theopilus Watuguly, Kustarini Samsuria Indranila, Suharyo Hadisaputro, Edi Dharmana, Lyle E. Craker
KEYWORDS:
Polyphenols, Lungs Carcinogenesis, Molecular Markers, p53, Bcl-2, Bax, Caspase-8, Caspase-9, Caspase-3
JOURNAL NAME:
Open Journal of Applied Sciences,
Vol.10 No.6,
June
2,
2020
ABSTRACT: Phytochemical analysis shows that mahkota dewa fruit contains
polyphenols. Mahkota dewa polyphenols have the ability to disrupt or reverse
the stages of cancer or a carcinogenesis process by affecting the intracellular
signaling tissue molecules involved in an initiation and/or promotion. This
chemopreventive potential is highly anticipating. The use, effectiveness, and
benefits of the polyphenol have been empirically and pre-clinically proved
without side effects. A multivariate analysis using Spearman’s test was
conducted to examine the correlation between variables. Meanwhile, to determine
which dependent variables played the strong role, a discriminant function analysis
was performed with a significance level of p