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Crossan, C., Tsochatzis, E.A., Longworth, L., Gurusamy, K., Davidson, B., Rodríguez-Perálvarez, M., Mantzoukis, K., O’Brien, J., Thalassinos, E., Papastergiou, V. and Burroughs, A. (2015) Cost-Effectiveness of Non-Invasive Methods for Assessment and Monitoring of Liver Fibrosis and Cirrhosis in Patients with Chronic Liver Disease: Systematic Review and Economic Evaluation. Health Technology Assessment, 19, 1-410.
https://doi.org/10.3310/hta19090

has been cited by the following article:

• TITLE: Evaluation of HBsAg Quantification as Surrogate to HBV DNA Viral Load in Hepatitis B Infected Patients in Anambra State, Nigeria

  AUTHORS: Chinwe Obiomah, Grace Amilo, Israel Ndulue

  KEYWORDS: Hepatis B Virus, HBsAg Quantification, HBV DNA

  JOURNAL NAME: American Journal of Molecular Biology, Vol.10 No.3, June 1, 2020

  ABSTRACT: Hepatitis B is an infectious disease of great public health importance. Nigeria is one of the countries with the highest incidence of Hepatitis B Virus (HBV) infection worldwide. However, the accessibility and affordability of HBV DNA quantification (viral load) assay is the key laboratory test for therapy initiation, and monitoring is a challenge to HBV management. This study aimed at determining the relationship between HBV DNA quantification and routine haemato-serological parameters in order to develop a more cost-effective diagnostic algorithm for Hepatitis B management. Cross sectional study design was used with a total of 264 subjects comprising of 88 HBsAg seropositive treatment naïve subjects, 88 HBsAg seropositive subjects on antiviral therapy as case subjects and 88 age-matched apparently healthy HBsAg seronegative individuals were recruited as control subjects. Hepatitis B Virus DNA assay was performed using real time PCR technique while ELISA technique was used for Hepatitis B surface antigen quantification. HBsAg quantification showed strong positive correlation with HBV DNA viral load both in treatment and non-treatment groups (r = 0.673; p